結構生物資訊
Structural Bioinformatics
學期
106-1
學分
0
學分
當期課號
5723
永久課號
IBI5165
開課單位
生物資訊及系統生物研究所
授課教師
楊進木
類別
選修
上課時間表
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 結構生物資訊 BA301 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
概述
Studying the methods and concepts of computational drug design, such as docking, screening, lead optimization, machine learning methods and algorithms, scoring function, and databases.
先修科目
None
備註
無備註
教學方式
Papers & public databases
評分方式
Homework (40%): Progress report or paper report Final project (40%) Examination: 20%
課程大綱
教師未提供此項資料
週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction to Structure Biology |
| 第 2 週 | Pairwise Sequence Alignment (BLAST Dynamic Programming) |
| 第 3 週 | Scoring matrix: BLOSUM-62 matrix |
| 第 4 週 | Multiple String Alignment (ClustalW and T-COFFEE) |
| 第 5 週 | Fundamentals of Protein Structures (Protein Data Bank)) |
| 第 6 週 | Molecular Visualization [Swiss PdbViewer) |
| 第 7 週 | Secondary structure prediction (DSSP, PHD: Neural Networks) |
| 第 8 週 | Structural Alignment (CE and 3D-BLAST) |
| 第 9 週 | Protein structure classification & databases (SCOP & CATH ) |
| 第 10 週 | Fold assignment & Fold Recognition (Support Vector Machine) |
| 第 11 週 | Homology Model (Swiss-Model and PS2) |
| 第 12 週 | Protein-Protein Interaction Prediction (Bayesian network ) |
| 第 13 週 | Protein-ligand docking (Genetic Algorithm) - 1 |
| 第 14 週 | Protein-ligand docking (Genetic Algorithm) - 2 |
| 第 15 週 | Compound similar search and clustering (Decision tree) |
| 第 16 週 | Structural Protein-Protein Interaction network |
| 第 17 週 | Metabolic pathways (KEGG) |
教科書
Papers: over one paper for each topic
Office Hours
- 地點
- 308 室: 博愛校區 生科實驗一館
- 時間
- 2CD
- 聯絡方式
- 56942