分子免疫與系統性疾病概論
Molecular Immunology and Systemic Diseases
學期
107-2
學分
0
學分
當期課號
B263
永久課號
B0587
開課單位
藥理學研究所
授課教師
羅正汎、黎萬君
校區
陽明
類別
選修
上課時間表
| 節 | 週二 |
|---|---|
5 13:20–14:10 | 分子免疫與系統性疾病概論 YD226（陽明） 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
概述
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先修科目
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備註
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課程大綱
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週次計畫
| 週次 | 主題 |
|---|---|
| 第 1 週 | |
| 第 2 週 | Introduction |
| 第 3 週 | Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis |
| 第 4 週 | Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regenerationFatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes |
| 第 5 週 | Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells |
| 第 6 週 | Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteinsImproving the metabolic fidelity of cancer models with a physiological cell culture medium |
| 第 7 週 | Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed MitophagyIntegrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia |
| 第 8 週 | Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytesAge-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration |
| 第 9 週 | 期中考周 |
| 第 10 週 | Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner |
| 第 11 週 | Improving the metabolic fidelity of cancer models with a physiological cell culture mediumEukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation |
| 第 12 週 | The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis6-Gingerol Improves Ectopic Lipid Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC-1α Signaling Pathway via Plasma Adiponectin and Muscular AdipoR1 |
| 第 13 週 | |
| 第 14 週 | |
| 第 15 週 | |
| 第 16 週 | |
| 第 17 週 | |
| 第 18 週 |
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