幹細胞生物學
Stem Cell Biology
| 節 | 週四 |
|---|---|
5 13:20–14:10 | 幹細胞生物學 3 節連堂 |
6 14:20–15:10 | |
7 15:30–16:20 |
* 根據陽明交大上課時間表所列
本課程介紹各式幹細胞的研究與應用,包括胚胎幹細胞及體幹細胞例如造血、間葉、生 殖、神經、表皮、心臟、角膜、肝臟、肺臟及胰臟等組織幹細胞,同時本課程也將說明 什麼是腫瘤幹細胞。本課程將透過基礎觀念的建立與了解,循序漸進介紹細胞生長調 節、幹細胞研究方法、幹細胞分化的調控機制;也會介紹 Phage display、CRISPR 等技 術如何應用在幹細胞研究。同時配合指定文獻的閱讀與報告中,以建立學生對幹細胞研 究思考判斷的能力。The Stem Cell Biology Course is primarily consisted of a series of lectures which covers from basics of the general biology of stem cells to a more in-depth discussion on various stem cell types: embryonic stem cells, adult somatic stem cells and cancer stem cells, and finally to some of their potential clinical application/implication. The course will also introduce how phage display technique and CRISPR tools can be used in stem cell research. For evaluation, students are required to write a review essay on designated research topics so that they can horn their skills in the search, organization and critical assessment of literatures.
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無備註
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(i) A written essay on a selected topics 40 % (ii) A short presentation on a selected topics (10 min) 40 % (ii) Attendance 20 %
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| 週次 | 主題 |
|---|---|
| 第 1 週 | Expansion and differentiation of hematopoietic stem cells Introduction to CRISPR/Cas technique and its applications |
| 第 2 週 | Stem cell therapy for cardiac regeneration |
| 第 3 週 | Embryonic stem cells & induced pluripotency |
| 第 4 週 | Derivation of ES cells from somatic cell nuclear transfer Niche Regulation in Germ Cell Pluripotency and Somatic Cancer |
| 第 5 週 | Brain organoids: generation, degeneration and regeneration Commercialization of the stem cell products |
| 第 6 週 | Stem cells in digestive system |
| 第 7 週 | Stem cell therapy in metabolic diseases Applications of stem cells in Ophthalmology |
| 第 8 週 | Hair follicle stem cell and hair regeneration Lung stem cells |
| 第 9 週 | Hematopoietic stem cells and their fate determination Mechanisms & Application of Mesenchymal Stem Cell Immunomodulation |
| 第 10 週 | Interaction between stem cells and niche for maintaining regeneration throughout life Mesenchymal Stem Cells Application in Cartilage Repair and Osteoarthritis |
| 第 11 週 | Cancer stem cells and cancer metastasis |
| 第 12 週 | Mouse Genetics Tools for Stem Cell Research Stem cell manipulation in GTP/GMP facilities |
| 第 13 週 | Epigenetic controls of cell fate |
| 第 14 週 | Student Presentation |
| 第 15 週 | |
| 第 16 週 | |
| 第 17 週 | |
| 第 18 週 |
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