蛋白質降解特論-中草藥於疾病治療的相關機制
Special Topic on Protein Degradation - The mechanisms of Chinese herbal medicine on diseases therapy
| 節 | 週一 |
|---|---|
5 13:20–14:10 | 蛋白質降解特論-中草藥於疾病治療的相關機制 YR102（陽明） 2 節連堂 |
6 14:20–15:10 |
* 根據陽明交大上課時間表所列
蛋白質降解是細胞中不可或缺的重要機制之一,其係經由一系列反應將蛋白質等進行瓦解成小片段胜肽或胺基酸,以利細胞再度回收重新製作出新蛋白質。然而,現今許多研究發現蛋白質降解系統的異常,往往會造成許多疾病發生,如癌症。本課程將介紹各式蛋白質降解機制並深入探討如何結合應用蛋白質降解機制探討中草藥研究於各式疾病治療之新穎策略。 Protein degradation is one of the most important mechanisms in cells. It uses a series of reactions to promote the proteins to digest into small fragments of peptide or amino acids, which can be used to produce a new protein. However, many studies show abnormalities in protein degradation systems often cause many diseases, such as cancer. This course will introduce a variety of protein degradation mechanisms and explore how use protein degradation systems to develop new strategies for various diseases treatment by Chinese herbal medicine.
細胞生物學
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1. 課堂參與(20%):上課出席率、課堂互動 2. 期中報告(40%)、期末報告(40%):文獻閱讀、口頭或書面報告
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| 週次 | 主題 |
|---|---|
| 第 1 週 | Brief History of Protein Degradation SystemUbiquitin-Proteasome System (UPS), Lysosome System, and Autophagy |
| 第 2 週 | UPS: N-terminal Ubiquitination |
| 第 3 週 | UPS: Ubiquitin-Protein Ligases and Deubiquitinating Enzymes |
| 第 4 週 | UPS: 26S Proteasome |
| 第 5 週 | UPS: Small Molecule Inhibitors and Molecular Probes |
| 第 6 週 | UPS: Functions of the Ubiquitin-Proteasome Pathway in Diseases I |
| 第 7 週 | UPS: Functions of the Ubiquitin-Proteasome Pathway in Diseases II (Paper-Reading) |
| 第 8 週 | UPS: Functions of the Ubiquitin-Proteasome Pathway in Diseases II (Paper-Reading) |
| 第 9 週 | Midterm Exam: Paper-Reading-Reports |
| 第 10 週 | Lysosome System |
| 第 11 週 | Autophagy |
| 第 12 週 | Autophagy: Macroautophagy system |
| 第 13 週 | Autophagy: The Relevance of UPS and Autophagy I |
| 第 14 週 | Autophagy: The Relevance of UPS and Autophagy II (Paper-Reading) |
| 第 15 週 | Autophagy: Functions of Autophagy in Diseases I |
| 第 16 週 | Autophagy: Functions of Autophagy in Diseases II (Small Molecule Inhibitors) |
1. R. John Mayer, Aaron J. Ciechanover, and Martin Rechsteiner. Protein Degradation Series, 4 Volume Set. ISBN: 978-3-527-31878-0. December 2007. 2. Klionsky D.J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.
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