老化生物學:基礎概論與轉譯醫學
The Biology of Aging : Concepts and Translational Medicine
| 節 | 週二 |
|---|---|
7 15:30–16:20 | 老化生物學:基礎概論與轉譯醫學 YK533（陽明） 2 節連堂 |
8 16:30–17:20 |
* 根據陽明交大上課時間表所列
As human life span progressively increases worldwide, knowledge of the effects of aging on human pathophysiology has become of great relevance to medicine. Therefore, developing strategies to maintain optimal health and to promote healthy aging in an increasingly aging human population is becoming a global challenge and an urgent need. This course aims to provide an overview of the fundamental concepts in modern gerontology, namely the biology of aging, and to review the latest and most important advances and themes in translational medicine. The course will cover the following parts: Part-I, basic mechanisms and pathways that associate with aging and longevity; Part-II, interventions that modulate aging and prolong healthspan in mammals.
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(1) Written reports on thematic topics (70%) (2) Oral presentation and written report on that presentation (30%)
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| 週次 | 主題 |
|---|---|
| 第 1 週 | Introduction: An overview of the biology of aging Hallmarks of aging: DNA damage and repair |
| 第 2 週 | Hallmarks of aging: Mitochondrial DNA and dysfunction |
| 第 3 週 | Hallmarks of aging: Deregulated nutrient-sensing (Sirtuins, mTOR and AMPK) |
| 第 4 週 | Hallmarks of aging: Cellular senescence, SASP and beyond |
| 第 5 週 | Oral presentation & Panel discussion-I |
| 第 6 週 | Hallmarks of aging: Dysbiosis |
| 第 7 週 | Biomarkers of aging: Evaluation of anti-aging and longevity interventions |
| 第 8 週 | Intervention: Dietary restriction and intermittent fasting |
| 第 9 週 | Oral presentation & Panel discussion-II |
| 第 10 週 | Intervention: Targeting Sirtuins, AMPK and mTOR |
| 第 11 週 | Intervention: Targeting senotherapeutics |
| 第 12 週 | Written report & Panel discussion-III |
| 第 13 週 | IHallmarks of aging & Intervention: Inflammaging and Autophagy |
| 第 14 週 | Intervention: Exercise and mimetics |
| 第 15 週 | Written report & Panel discussion-IV |
| 第 16 週 | Oral presentation & Panel discussion-V |
(1) Handbook of the Biology of Aging (ScienceDirect, 9th Edition, 2021; Nicolas Musi and Peter Hornsby) (2) Handouts: Review and research articles
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